Zhang Lei, Zhao Qian, Che Qilei, Wang Wenju, Chen Tao, Tang Xiao, Zhao Xin, Wang Nianou, Li Ke, Wa Qingbiao
Medical Cosmetic Center, Chengdu Second People's Hospital, Chengdu, China.
Department of Dermatology, Chengdu Second People's Hospital, Chengdu, China.
J Cosmet Dermatol. 2025 Feb;24(2):e70007. doi: 10.1111/jocd.70007.
Melasma and facial aging are prevalent dermatological concerns. The combined use of a home-based radiofrequency (RF) device and a topical depigmentation agent, such as an arbutin-based cream, has shown potential in addressing both conditions.
This study evaluated the effectiveness and safety of combining a home-based RF device with arbutin cream to treat melasma and facial aging.
This single-center, open-label study included 38 participants. The treatment involved using a home-based RF device alongside an arbutin cream three times a week for 4 weeks, followed by a 4-week rest period. Key outcomes included changes in modified Melasma Area and Severity Index (mMASI) scores, melanin index (MI), erythema index (EI), facial wrinkles, skin texture, and periorbital dermal thickness. The participants also provided a self-assessment of the treatment efficacy.
After 4 and 8 weeks of treatment, compared with baseline, the mMASI scores decreased by 20.8% and 25.6%, whereas the MI decreased by 22.0% and 22.8%, respectively. The EI decreased by 5.94% and 6.86%, facial wrinkles decreased by 30.9% and 35.9%, and skin texture scores decreased by 19.7% and 21.4% at 4 and 8 weeks posttreatment, respectively. Significant improvements in periorbital dermal thickness and subcutaneous tissue thickness were observed after combined RF and arbutin cream treatment. None of the 38 participants experienced adverse events, and all reported satisfaction with the results.
The combination of a noninvasive home-based RF device and arbutin cream is effective in improving melasma and achieving facial rejuvenation, offering a safe and patient-friendly treatment option.
黄褐斑和面部老化是常见的皮肤问题。在家使用射频（RF）设备与外用色素沉着抑制剂（如基于熊果苷的乳膏）联合使用，已显示出解决这两种问题的潜力。
本研究评估家用射频设备与熊果苷乳膏联合治疗黄褐斑和面部老化的有效性和安全性。
这项单中心、开放标签研究纳入了38名参与者。治疗方法是每周三次在家使用射频设备并同时使用熊果苷乳膏，持续4周，随后休息4周。主要观察指标包括改良黄褐斑面积和严重程度指数（mMASI）评分、黑色素指数（MI）、红斑指数（EI）、面部皱纹、皮肤质地和眶周真皮厚度的变化。参与者还对治疗效果进行了自我评估。
治疗4周和8周后，与基线相比，mMASI评分分别下降了20.8%和25.6%，而MI分别下降了22.0%和22.8%。治疗后4周和8周，EI分别下降了5.94%和6.86%，面部皱纹分别减少了30.9%和35.9%，皮肤质地评分分别下降了19.7%和21.4%。联合射频和熊果苷乳膏治疗后，眶周真皮厚度和皮下组织厚度有显著改善。38名参与者均未发生不良事件，且所有参与者均对结果表示满意。
无创家用射频设备与熊果苷乳膏联合使用可有效改善黄褐斑并实现面部年轻化，提供了一种安全且患者友好的治疗选择。
