Lloveras J J, Dupré-Goudable C, Rey J P, Sporer P, Durand D, Ton That H, Suc J M
Service de Néphrologie, CHU de Rangueil, Toulouse.
Presse Med. 1991 Nov 27;20(40):2016-8.
Following simultaneous liver-kidney transplantation for primary hyperoxaluria type I, although the missing enzyme is provided by the liver transplant, there is a risk of recurrent calcium oxalate crystal formation in the implanted kidney. The necessary kidney protection methods are extrarenal blood purification, principally haemodialysis and haemofiltration, and an abundant diuresis ensured by copious fluid intakes together with prescription of diuretics. These therapeutic measures reduce the oxalate concentrations in both blood and urine. Oxalates are excreted in large amounts over a long period, owing to the formation of important tissue deposits during systemic oxalosis.
在进行I型原发性高草酸尿症的肝肾联合移植后，尽管肝脏移植提供了缺失的酶，但植入的肾脏仍有复发草酸钙晶体形成的风险。必要的肾脏保护方法是肾外血液净化，主要是血液透析和血液滤过，并通过大量饮水以及使用利尿剂来确保充足的利尿。这些治疗措施可降低血液和尿液中的草酸盐浓度。由于全身性草酸中毒期间形成了重要的组织沉积物，草酸盐会在很长一段时间内大量排出。
