化疗与癌症干细胞。

Chemotherapy and cancer stem cells.

作者信息

Rich Jeremy N, Bao Shideng

机构信息

Department of Medicine, Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Cell Stem Cell. 2007 Oct 11;1(4):353-5. doi: 10.1016/j.stem.2007.09.011.

DOI:10.1016/j.stem.2007.09.011

PMID:18371369

Abstract

Cancer stem cells are subsets of tumor cells defined through the capacity to initiate tumors and have been linked to therapeutic resistance. In this issue of Cell Stem Cell, Todaro et al. (2007) demonstrate that targeting tumor IL-4 sensitizes colon cancer stem cells to chemotherapy.

摘要

癌症干细胞是通过引发肿瘤的能力定义的肿瘤细胞亚群，并且与治疗抗性相关。在本期《细胞·干细胞》杂志中，托达罗等人（2007年）证明，靶向肿瘤白细胞介素-4可使结肠癌干细胞对化疗敏感。