为什么是myc？干细胞混合物中的一种意外成分。

Why myc? An unexpected ingredient in the stem cell cocktail.

作者信息

Knoepfler Paul S

机构信息

Institute of Pediatric Regenerative Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA.

出版信息

Cell Stem Cell. 2008 Jan 10;2(1):18-21. doi: 10.1016/j.stem.2007.12.004.

DOI:10.1016/j.stem.2007.12.004

PMID:18371417

Abstract

Screening cocktails of candidate genes for induction of pluripotency and self-renewal in nonstem cells has identified a surprising new embryonic stem cell regulator, the myc proto-oncogene. Here the possible mechanisms by which myc controls self-renewal and pluripotency are discussed.

摘要

筛选用于诱导非干细胞多能性和自我更新的候选基因组合，已鉴定出一种令人惊讶的新型胚胎干细胞调节因子——原癌基因myc。本文讨论了myc控制自我更新和多能性的可能机制。