间充质基质细胞如何抑制T细胞？
How do mesenchymal stromal cells suppress T cells?
作者信息
Keating Armand
机构信息
Princess Margaret Hospital, 610 University Avenue, Suite 5-303, Toronto, ON M5G 2M9, Canada.
出版信息
Cell Stem Cell. 2008 Feb 7;2(2):106-8. doi: 10.1016/j.stem.2008.01.007.
PMID:18371428
Abstract
Accumulating information indicates that mesenchymal stem or stromal cells (MSCs) are immunomodulatory, but the data to explain the observations are frequently conflicting. In this issue of Cell Stem Cell, Ren et al. (2008) provide evidence for a possible underlying mechanism of MSC-mediated T cell suppression. A perspective for considering these interesting observations is discussed.
摘要
越来越多的信息表明，间充质干细胞（MSCs）具有免疫调节作用，但用以解释这些观察结果的数据常常相互矛盾。在本期的《细胞干细胞》杂志中，任等人（2008年）为MSCs介导的T细胞抑制作用的潜在机制提供了证据。本文讨论了对这些有趣观察结果的一种思考角度。
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