生殖系干细胞：遗传的第一道防线。
Germline stem cells: the first guards of heredity.
作者信息
Barroca Vilma, Fouchet Pierre
机构信息
CEA, DSV, iRCM, SCSR, Laboratoire Gamétogenèse, Apoptose, Genotoxicité and INSERM, Unité 566, F-92265, Fontenay aux Roses, France.
出版信息
Cell Stem Cell. 2008 Feb 7;2(2):108-10. doi: 10.1016/j.stem.2008.01.006.
PMID:18371429
Abstract
The genes involved in the cellular response to DNA damage are crucial for ensuring DNA integrity during spermatogenesis. In this issue of Cell Stem Cell, Takubo et al. (2008) show that ATM, a key kinase of the DNA damage response, is also involved in maintaining the stem cell potential of undifferentiated spermatogonia.
摘要
参与细胞对DNA损伤反应的基因对于确保精子发生过程中的DNA完整性至关重要。在本期《细胞干细胞》杂志中，Takubo等人（2008年）表明，ATM作为DNA损伤反应的关键激酶，也参与维持未分化精原细胞的干细胞潜能。
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