共济失调毛细血管扩张症突变激酶（ATM）作为辐射诱导的DNA损伤反应的核心调节因子。
Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response.
作者信息
Tichý Ales, Vávrová Jirina, Pejchal Jaroslav, Rezácová Martina
机构信息
University of Defence in Brno, Faculty of Military Health Sciences, Department of Radiobiology, Hradec Králové, Czech Republic.
出版信息
Acta Medica (Hradec Kralove). 2010;53(1):13-7. doi: 10.14712/18059694.2016.57.
Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key regulatory enzyme in the terms of ionizing radiation-induced DNA damage.
共济失调毛细血管扩张症突变激酶（ATM）是一种DNA损伤诱导蛋白激酶，它能磷酸化大量参与DNA损伤反应的底物。ATM对细胞命运的重要性不可否认，因为它调节DNA修复、细胞周期进程和细胞凋亡。在此，我们描述其主要信号靶点，并从电离辐射诱导的DNA损伤角度讨论其在DNA修复中的重要性以及与这种关键调节酶相关的新发现。
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