Havlikova Eva, van Dijk Jitse P, Rosenberger Jaroslav, Nagyova Iveta, Middel Berrie, Dubayova Tatiana, Gdovinova Zuzana, Groothoff Johan W
Safarik University Kosice, Faculty of Medicine, Department of Neurology, Kosice, Slovakia.
J Neurol Sci. 2008 Jul 15;270(1-2):107-13. doi: 10.1016/j.jns.2008.02.013. Epub 2008 Mar 26.
Many patients with Parkinson's disease (PD) suffer from non-motor symptoms like sleep disturbances, excessive daytime sleepiness and fatigue. The aim of our research was to explore whether fatigue is related to sleepiness and sleep problems, depression and functional status, controlled for age, gender and disease duration.
The sample consisted of 78 PD patients from Eastern Slovakia (52% males, mean age 68.8+/-8.7, mean disease duration 7.2+/-6.8). The Multidimensional Fatigue Inventory (5 dimensions), the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale and the Unified Parkinson's Disease Rating Scale were used. Demographic data were obtained in a structured interview. Multiple linear regression was used to analyse the data.
Sleepiness did not show significant association with fatigue in any of the fatigue domains; neither did quality of sleep. Depression was significantly associated with all domains of fatigue, the strongest being the relationship with general fatigue (beta .42), reduced motivation (beta .39), mental fatigue (beta .35) (p<.001), and physical fatigue (beta .31) (p<.01), while the relationship with reduced activity was less strong (beta .22) (p<.05). Worse functional status was significantly related to reduced activity (beta .50), general fatigue (beta .35), physical fatigue (beta .35), and mental fatigue (beta .35) (p<.001).
Fatigue is not related to daytime sleepiness or night-time sleep dysfunction. Fatigue is more strongly influenced by the presence of depression and worse functional status.
许多帕金森病（PD）患者存在睡眠障碍、日间过度嗜睡和疲劳等非运动症状。我们研究的目的是探讨疲劳是否与嗜睡、睡眠问题、抑郁及功能状态相关，并对年龄、性别和病程进行控制。
样本包括来自斯洛伐克东部的78例PD患者（男性占52%，平均年龄68.8±8.7岁，平均病程7.2±6.8年）。使用多维疲劳量表（5个维度）、爱泼沃斯嗜睡量表、匹兹堡睡眠质量指数、医院焦虑抑郁量表和统一帕金森病评定量表。通过结构化访谈获取人口统计学数据。采用多元线性回归分析数据。
在任何疲劳领域，嗜睡与疲劳均未显示出显著相关性；睡眠质量也未显示出相关性。抑郁与所有疲劳领域均显著相关，与总体疲劳（β=0.42）、动力下降（β=0.39）、精神疲劳（β=0.35）（p<0.001）及身体疲劳（β=0.31）（p<0.01）的相关性最强，而与活动减少的相关性较弱（β=0.22）（p<0.05）。较差的功能状态与活动减少（β=0.50）、总体疲劳（β=0.35）、身体疲劳（β=0.35）及精神疲劳（β=0.35）显著相关（p<0.001）。
疲劳与日间嗜睡或夜间睡眠功能障碍无关。抑郁的存在及较差的功能状态对疲劳的影响更大。
