白天嗜睡与帕金森病的跌倒有关。
Daytime sleepiness is associated with falls in Parkinson's disease.
机构信息
Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Parkinson's Disease Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA.
出版信息
J Parkinsons Dis. 2013 Jan 1;3(3):387-91. doi: 10.3233/JPD-130184.
Abstract
Falls are frequent in Parkinson's disease (PD), and may be influenced by daytime sleepiness. We reviewed the records of 120 men with PD. Mean Epworth Sleepiness Scale (ESS) values were significantly different between non-fallers and fallers (6.0 vs. 9.7, p < 0.01). In multivariate analysis, ESS remained significantly associated with falls (OR 1.2, 95% CI 1.1-1.4, p = 0.02), along with cognitive impairment (OR 4.4 95% CI 1.0-18.7, p = 0.04) and postural instability/gait dysfunction (OR 1.6 95% CI 1.0-2.4, p = 0.03) in non-depressed patients. In conclusion, non-depressed PD patients are 20% more likely to fall for every one unit increase in the ESS measure of sleepiness.
摘要
帕金森病（PD）患者经常跌倒，白天嗜睡可能会对此产生影响。我们回顾了 120 名男性 PD 患者的记录。非跌倒者和跌倒者的平均 Epworth 嗜睡量表（ESS）值存在显著差异（6.0 与 9.7，p < 0.01）。在多变量分析中，ESS 与跌倒显著相关（OR 1.2，95%CI 1.1-1.4，p = 0.02），与认知障碍（OR 4.4，95%CI 1.0-18.7，p = 0.04）和姿势不稳定/步态障碍（OR 1.6，95%CI 1.0-2.4，p = 0.03）在非抑郁患者中也相关。总之，非抑郁的 PD 患者的 ESS 嗜睡测量值每增加一个单位，跌倒的可能性就会增加 20%。
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