Shi Benkang, Zhang Keqin, Zhang Jing, Chen Jun, Zhang Nianzhao, Xu Zhishun
Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Urology. 2008 Jun;71(6):1186-90. doi: 10.1016/j.urology.2008.01.062. Epub 2008 Apr 18.
To evaluate the relationship between patient age and the characteristics of superficial transitional cell carcinoma.
The clinical and pathologic records of 576 patients were retrospectively reviewed. The patients were classified into three groups: those 40 years or younger, those 41 to 59 years old, and those 60 years or older. The transitional cell carcinoma characteristics of three groups were analyzed to define the relationship, if any, with age.
The male/female ratio was 4.1:1, 3.6:1, and 2.3:1 in the three age groups, with significant differences between the 60 years or older group and the 40 years or younger group and 41 to 59 year group (P <0.05). The percentage of patients with poorly differentiated tumor increased with increasing age, and a significant difference was found between the 60 years or older group and the 40 years or younger and 41 to 59 year groups (P <0.05). The overall recurrence rate was 34.2% at 12 months and 40.8% at 24 months. The nonrecurrence rate was significantly greater in those 40 years or younger compared with those 60 years or older in all three risk groups (P <0.05).
The results of our study have shown that the percentage of female patients with bladder cancer increases with increasing age and that elderly patients are more likely to present with poorly differentiated bladder cancer. Also, the recurrence-free survival rate decreased with increasing age.
评估患者年龄与浅表性移行细胞癌特征之间的关系。
回顾性分析576例患者的临床和病理记录。将患者分为三组：40岁及以下、41至59岁、60岁及以上。分析三组的移行细胞癌特征，以确定与年龄的关系（若有）。
三个年龄组的男女比例分别为4.1:1、3.6:1和2.3:1，60岁及以上组与40岁及以下组以及41至59岁组之间存在显著差异（P<0.05）。低分化肿瘤患者的百分比随年龄增长而增加，60岁及以上组与40岁及以下组以及41至59岁组之间存在显著差异（P<0.05）。12个月时的总体复发率为34.2%，24个月时为40.8%。在所有三个风险组中，40岁及以下患者的无复发率显著高于60岁及以上患者（P<0.05）。
我们的研究结果表明，膀胱癌女性患者的百分比随年龄增长而增加，老年患者更易出现低分化膀胱癌。此外，无复发生存率随年龄增长而降低。
