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体外受精前的人工流产:一项基于芬兰流行病学登记的研究

Induced abortions previous to IVF: an epidemiologic register-based study from Finland.

作者信息

Hemminki E, Klemetti R, Sevón T, Gissler M

机构信息

National Research and Development Centre for Welfare and Health (STAKES), PO Box 220, 00531 Helsinki, Finland.

出版信息

Hum Reprod. 2008 Jun;23(6):1320-3. doi: 10.1093/humrep/den101. Epub 2008 Mar 27.

Abstract

BACKGROUND

The purpose of this study was to identify how many women treated for infertility had an abortion history, as well as when those abortions were carried out, and for what reasons.

METHODS

Data on all women treated in Finland from 1996-1998 for infertility either with IVF (n = 9175) or ovulation induction (OI, n = 10,254) and the age-matched controls of IVF women were linked to the Abortion and Hospital Discharge Registers for the period 1969-2000.

RESULTS

A notable proportion of IVF women (12%) and OI women (11%) had previous induced abortion(s). Practically all abortions were for social or age reasons. Most IVF women (72% of n = 1099) had their most recent abortion more than 10 years previous to fertility treatment, but more recently among OI women (45% of n = 1123 of the most recent abortions were in the preceding 10 years). Many IVF- and OI women were young and single at the time of the most recent abortion. At the time of IVF treatment most women were aged over 30 and married; OI women were also frequently married, but 42% of them were aged younger than 30.

CONCLUSIONS

At different points in their life, women may rely on opposite fertility regulation strategies. Health care professionals providing IVF need to consider the possibility of a previous abortion. Young women need information on the possibility of future infertility in later age.

摘要

背景

本研究旨在确定接受不孕症治疗的女性中有堕胎史的人数、堕胎时间以及原因。

方法

1996年至1998年在芬兰接受体外受精(IVF,n = 9175)或促排卵(OI,n = 10254)治疗的所有女性的数据,以及IVF女性的年龄匹配对照组的数据,与1969年至2000年期间的堕胎和医院出院登记数据相关联。

结果

相当比例的IVF女性(12%)和OI女性(11%)有过人工流产史。几乎所有堕胎都是出于社会或年龄原因。大多数IVF女性(n = 1099中的72%)在接受生育治疗前10多年进行了最近一次堕胎,但在OI女性中,最近一次堕胎在过去10年的比例更高(n = 1123中的45%)。许多IVF和OI女性在最近一次堕胎时年轻且单身。在接受IVF治疗时,大多数女性年龄超过30岁且已婚;OI女性也经常已婚,但其中42%的年龄小于30岁。

结论

在人生的不同阶段,女性可能会依赖相反的生育调节策略。提供IVF治疗的医疗保健专业人员需要考虑先前堕胎的可能性。年轻女性需要了解未来晚年不孕的可能性。

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