3-T磁共振成像下软骨的T2评估：两种软骨修复术后正常透明软骨与修复组织的体内鉴别——初步经验

Cartilage T2 assessment at 3-T MR imaging: in vivo differentiation of normal hyaline cartilage from reparative tissue after two cartilage repair procedures--initial experience.

作者信息

Welsch Goetz H, Mamisch Tallal C, Domayer Stephan E, Dorotka Ronald, Kutscha-Lissberg Florian, Marlovits Stefan, White Lawrence M, Trattnig Siegfried

机构信息

MR Center, Department of Radiology, Medical University of Vienna, Lazarettgasse 14, A-1090 Vienna, Austria.

出版信息

Radiology. 2008 Apr;247(1):154-61. doi: 10.1148/radiol.2471070688.

DOI:10.1148/radiol.2471070688

PMID:18372466

Abstract

PURPOSE

To prospectively compare cartilage T2 values after microfracture therapy (MFX) and matrix-associated autologous chondrocyte transplantation (MACT) repair procedures.

MATERIALS AND METHODS

The study had institutional review board approval by the ethics committee of the Medical University of Vienna; informed consent was obtained. Twenty patients who underwent MFX or MACT (10 in each group) were enrolled. For comparability, patients of each group were matched by mean age (MFX, 40.0 years +/- 15.4 [standard deviation]; MACT, 41.0 years +/- 8.9) and postoperative interval (MFX, 28.6 months +/- 5.2; MACT, 27.4 months +/- 13.1). Magnetic resonance (MR) imaging was performed with a 3-T MR imager, and T2 maps were calculated from a multiecho spin-echo measurement. Global, as well as zonal, quantitative T2 values were calculated within the cartilage repair area and within cartilage sites determined to be morphologically normal articular cartilage. Additionally, with consideration of the zonal organization, global regions of interest were subdivided into deep and superficial areas. Differences between cartilage sites and groups were calculated by using a three-way analysis of variance.

RESULTS

Quantitative T2 assessment of normal native hyaline cartilage showed similar results for all patients and a significant trend of increasing T2 values from deep to superficial zones (P < .05). In cartilage repair areas after MFX, global mean T2 was significantly reduced (P < .05), whereas after MACT, mean T2 was not reduced (P > or = .05). For zonal variation, repair tissue after MFX showed no significant trend between different depths (P > or = .05), in contrast to repair tissue after MACT, in which a significant increase from deep to superficial zones (P < .05) could be observed.

CONCLUSION

Quantitative T2 mapping seems to reflect differences in repair tissues formed after two surgical cartilage repair procedures. (c) RSNA, 2008.

摘要

目的

前瞻性比较微骨折治疗（MFX）和基质相关自体软骨细胞移植（MACT）修复术后软骨的T2值。

材料与方法

本研究经维也纳医科大学伦理委员会批准，获得机构审查委员会认可，并取得了知情同意书。纳入20例行MFX或MACT治疗的患者（每组10例）。为保证可比性，每组患者按平均年龄（MFX组，40.0岁±15.4[标准差]；MACT组，41.0岁±8.9）和术后间隔时间（MFX组，28.6个月±5.2；MACT组，27.4个月±13.1）进行匹配。采用3-T磁共振成像仪进行磁共振（MR）成像，并通过多回波自旋回波测量计算T2图。在软骨修复区域以及形态学上判定为正常关节软骨的部位计算整体和分区的定量T2值。此外，考虑到分区结构，将整体感兴趣区域细分为深部和浅部区域。采用三因素方差分析计算软骨部位和组间的差异。

结果

对所有患者正常天然透明软骨进行定量T2评估，结果相似，且T2值从深部到浅部区域有显著升高趋势（P<.05）。MFX术后软骨修复区域的整体平均T2值显著降低（P<.05），而MACT术后平均T2值未降低（P≥.05）。对于分区变化，MFX术后修复组织在不同深度之间无显著趋势（P≥.05），而MACT术后修复组织从深部到浅部区域有显著升高（P<.05）。