填充有化疗药物的碳纳米管：一种介导肿瘤细胞生长抑制的纳米载体。
Carbon nanotubes filled with a chemotherapeutic agent: a nanocarrier mediates inhibition of tumor cell growth.
作者信息
Hampel Silke, Kunze Doreen, Haase Diana, Krämer Kai, Rauschenbach Mandy, Ritschel Manfred, Leonhardt Albrecht, Thomas Jürgen, Oswald Steffen, Hoffmann Volker, Büchner Bernd
机构信息
Leibniz Institute for Solid State and Materials Research Dresden, PF 270116, 01171 Dresden, Germany.
出版信息
Nanomedicine (Lond). 2008 Apr;3(2):175-82. doi: 10.2217/17435889.3.2.175.
AIM
In this paper, carbon nanotubes (CNTs) are presented as feasible carriers for carboplatin, a therapeutic agent for cancer treatment. The drug was introduced into CNTs to demonstrate that they are suited as nanocontainers and nanocarriers and can release the drug to initialize its medical virtue.
METHOD
The filling was accomplished by a wet-chemical approach after the CNTs were opened. The effect on cell proliferation and cytotoxicity of the carboplatin-filled CNT was investigated by using a viability assays.
RESULTS
Using different analysis methods such as electron energy loss spectroscopy and x-ray photoelectron spectroscopy the structure of carboplatin incorporated into the CNTs was found to be retained. In vitro studies showed that carboplatin-filled CNTs inhibited growth of bladder cancer cells whereas unfilled, opened CNTs barely affected cancer cell growth.
CONCLUSION
A reversible filling-emptying process could be performed successfully within this work. This highlights the potential of CNTs for applications in the field of drug delivery.
目的
在本文中，碳纳米管（CNTs）被视为顺铂（一种癌症治疗药物）的可行载体。将该药物引入碳纳米管以证明它们适合作为纳米容器和纳米载体，并能释放药物以发挥其医学功效。
方法
在碳纳米管打开后，通过湿化学方法完成填充。使用活力测定法研究了填充顺铂的碳纳米管对细胞增殖和细胞毒性的影响。
结果
通过使用不同的分析方法，如电子能量损失谱和X射线光电子能谱，发现掺入碳纳米管中的顺铂结构得以保留。体外研究表明，填充顺铂的碳纳米管抑制膀胱癌细胞的生长，而未填充、打开的碳纳米管几乎不影响癌细胞的生长。
结论
在这项工作中可以成功地进行可逆的填充-排空过程。这突出了碳纳米管在药物递送领域应用的潜力。
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