含有多种抗体和寡核苷酸用于多靶点药物递送的聚（苹果酸）纳米共轭物。
Poly(malic acid) nanoconjugates containing various antibodies and oligonucleotides for multitargeting drug delivery.
作者信息
Ljubimova Julia Y, Fujita Manabu, Ljubimov Alexander V, Torchilin Vladimir P, Black Keith L, Holler Eggehard
机构信息
Cedars-Sinai Medical Center, Department of Neurosurgery, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA.
出版信息
Nanomedicine (Lond). 2008 Apr;3(2):247-65. doi: 10.2217/17435889.3.2.247.
Nanoconjugates are emerging as promising drug-delivery vehicles because of their multimodular structure enabling them to actively target discrete cells, pass through biological barriers and simultaneously carry multiple drugs of various chemical nature. Nanoconjugates have matured from simple devices to multifunctional, biodegradable, nontoxic and nonimmunogenic constructs, capable of delivering synergistically functioning drugs in vivo. This review mainly concerns the Polycefin family of natural-derived polymeric drug-delivery devices as an example. This type of vehicle is built by hierarchic conjugation of functional groups onto the backbone of poly(malic acid), an aliphatic polyester obtained from the microorganism Physarum polycephalum. Particular Polycefin variants target human brain and breast tumors implanted into animals specifically and actively and could be detected easily by noninvasive imaging analysis. Delivery of antisense oligonucleotides to a tumor-specific angiogenic marker using Polycefin resulted in significant inhibition of tumor angiogenesis and increase of animal survival.
纳米缀合物正作为一种有前景的药物递送载体而兴起，因为其多模块结构使其能够主动靶向离散细胞、穿过生物屏障并同时携带多种具有不同化学性质的药物。纳米缀合物已从简单的装置发展成为多功能、可生物降解、无毒且无免疫原性的构建体，能够在体内递送具有协同作用的药物。本综述主要以天然衍生的聚合物药物递送装置聚西芬家族为例。这类载体是通过将官能团分层缀合到聚（苹果酸）主链上构建而成，聚（苹果酸）是一种从多头绒泡菌微生物中获得的脂肪族聚酯。特定的聚西芬变体能够特异性且主动地靶向植入动物体内的人脑肿瘤和乳腺肿瘤，并且可以通过非侵入性成像分析轻松检测到。使用聚西芬将反义寡核苷酸递送至肿瘤特异性血管生成标志物可显著抑制肿瘤血管生成并延长动物存活时间。
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