用于脑肿瘤选择性成像和治疗的共价纳米递送系统。
Covalent nano delivery systems for selective imaging and treatment of brain tumors.
作者信息
Ljubimova Julia Y, Sun Tao, Mashouf Leila, Ljubimov Alexander V, Israel Liron L, Ljubimov Vladimir A, Falahatian Vida, Holler Eggehard
机构信息
Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd., AHSP, Los Angeles, CA 90048, USA.
Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd., AHSP, Los Angeles, CA 90048, USA.
出版信息
Adv Drug Deliv Rev. 2017 Apr;113:177-200. doi: 10.1016/j.addr.2017.06.002. Epub 2017 Jun 10.
Nanomedicine is a rapidly evolving form of therapy that holds a great promise for superior drug delivery efficiency and therapeutic efficacy than conventional cancer treatment. In this review, we attempt to cover the benefits and the limitations of current nanomedicines with special attention to covalent nano conjugates for imaging and drug delivery in the brain. The improvement in brain tumor treatment remains dismal despite decades of efforts in drug development and patient care. One of the major obstacles in brain cancer treatment is the poor drug delivery efficiency owing to the unique blood-brain barrier (BBB) in the CNS. Although various anti-cancer agents are available to treat tumors outside of the CNS, the majority fails to cross the BBB. In this regard, nanomedicines have increasingly drawn attention due to their multi-functionality and versatility. Nano drugs can penetrate BBB and other biological barriers, and selectively accumulate in tumor cells, while concurrently decreasing systemic toxicity.
纳米医学是一种快速发展的治疗形式，与传统癌症治疗相比，它在提高药物递送效率和治疗效果方面具有巨大潜力。在这篇综述中，我们试图涵盖当前纳米药物的优点和局限性，特别关注用于脑部成像和药物递送的共价纳米缀合物。尽管在药物开发和患者护理方面经过了数十年的努力，但脑肿瘤治疗的改善仍然不尽人意。脑癌治疗的主要障碍之一是由于中枢神经系统中独特的血脑屏障（BBB）导致药物递送效率低下。尽管有各种抗癌药物可用于治疗中枢神经系统以外的肿瘤，但大多数药物无法穿过血脑屏障。在这方面，纳米药物因其多功能性和通用性而越来越受到关注。纳米药物可以穿透血脑屏障和其他生物屏障，并选择性地在肿瘤细胞中积累，同时降低全身毒性。
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