疟原虫色素：油相还是水相。
Hemozoin: oil versus water.
作者信息
Pisciotta John M, Sullivan David
机构信息
The Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe St., Baltimore, MD 21205, USA.
出版信息
Parasitol Int. 2008 Jun;57(2):89-96. doi: 10.1016/j.parint.2007.09.009. Epub 2007 Oct 13.
Abstract
Because the quinolines inhibit heme crystallization within the malaria parasite much work has focused on mechanism of formation and inhibition of hemozoin. Here we review the recent evidence for heme crystallization within lipids in diverse parasites and the new implications of a lipid site of crystallization for drug targeting. Within leukocytes hemozoin can generate toxic radical lipid metabolites, which may alter immune function or reduce deformability of uninfected erythrocytes.
摘要
由于喹啉类药物抑制疟原虫体内的血红素结晶，许多研究工作都集中在疟原虫血红素的形成机制及抑制方面。在此，我们综述了不同寄生虫中脂质内血红素结晶的最新证据，以及脂质结晶位点对药物靶向作用的新启示。在白细胞内，疟原虫血红素可生成有毒的自由基脂质代谢产物，这可能会改变免疫功能或降低未感染红细胞的变形能力。
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