上睑提肌在老年性上睑下垂中的功能
Levator superioris muscle function in involutional blepharoptosis.
作者信息
Pereira Luciano S, Hwang Thomas N, Kersten Robert C, Ray Kathryn, McCulley Timothy J
机构信息
Department of Ophthalmology, University of California-San Francisco, 10 Koret Way, San Francisco, CA 94143, USA.
出版信息
Am J Ophthalmol. 2008 Jun;145(6):1095-1098. doi: 10.1016/j.ajo.2008.02.002. Epub 2008 Mar 28.
PURPOSE
To assess the role of muscular degeneration, we evaluated the correlation between ptosis severity and levator muscle function.
DESIGN
Retrospective cohort study.
METHODS
The medical records of 136 patients (53 men and 83 women; mean age, 67 years) with acquired blepharoptosis were reviewed for levator function (LF), margin reflex distance (MRD), age, and gender. Multivariate linear regression was performed for statistical analysis.
RESULTS
A significant correlation (P < .001) was seen between MRD (mean, 1.0 + 1.0 mm; range, -3.0 to 3.0 mm) and LF (mean, 15.0 + 1.0 mm; range, 11.0 to 20.0 mm). On average, a 0.5-mm reduction in LF was observed for each 1.0-mm decrease in MRD. This was independent to other variables assessed.
CONCLUSIONS
In patients with involutional blepharoptosis, a directly proportional decrease in levator function and eyelid height was observed. This may implicate an abnormality of the levator muscle itself as a contributing factor in the development of involutional blepharoptosis.
目的
为评估肌肉退化的作用，我们评估了上睑下垂严重程度与提上睑肌功能之间的相关性。
设计
回顾性队列研究。
方法
回顾了136例获得性上睑下垂患者（53例男性和83例女性；平均年龄67岁）的病历，记录提上睑肌功能（LF）、边缘反射距离（MRD）、年龄和性别。采用多变量线性回归进行统计分析。
结果
MRD（平均值为1.0 + 1.0 mm；范围为-3.0至3.0 mm）与LF（平均值为15.0 + 1.0 mm；范围为11.0至20.0 mm）之间存在显著相关性（P < .001）。平均而言，MRD每降低1.0 mm，LF降低0.5 mm。这与评估的其他变量无关。
结论
在退行性上睑下垂患者中，观察到提上睑肌功能和眼睑高度呈正比下降。这可能意味着提上睑肌本身的异常是退行性上睑下垂发生的一个促成因素。
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