2-芳基苯并恶唑类化合物作为新型胆固醇酯转移蛋白抑制剂：通过阵列合成进行优化
2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.
作者信息
Harikrishnan Lalgudi S, Kamau Muthoni G, Herpin Timothy F, Morton George C, Liu Yalei, Cooper Christopher B, Salvati Mark E, Qiao Jennifer X, Wang Tammy C, Adam Leonard P, Taylor David S, Chen Alice Ye A, Yin Xiaohong, Seethala Ramakrishna, Peterson Tara L, Nirschl David S, Miller Arthur V, Weigelt Carolyn A, Appiah Kingsley K, O'Connell Jonathan C, Michael Lawrence R
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA.
出版信息
Bioorg Med Chem Lett. 2008 Apr 15;18(8):2640-4. doi: 10.1016/j.bmcl.2008.03.030. Epub 2008 Mar 14.
2-Arylbenzoxazole 5 was identified as a hit from a fluorescence-based high-throughput screen for CETP inhibitors. The synthesis and SAR investigation employing array synthesis of the A- and B-rings are described.
2-芳基苯并恶唑5是通过基于荧光的CETP抑制剂高通量筛选鉴定出的活性化合物。本文描述了采用A环和B环阵列合成法进行的合成及构效关系研究。
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