Barbieri E, Tanganelli P, Taddei G, Attino V, Molinari G, Mirandola G, Cosimi A, Destro G
Divisione Clinicizzata di Cardiologia, Università degli Studi, Verona.
Cardiologia. 1991 Jun;36(6):461-7.
Restenosis is the major limit of arterial recanalization devices. Directional atherectomy has allowed for the first to remove atheroma samples by a percutaneous approach. A group of patients affected by superficial femoral artery disease who underwent directional atherectomy were studied. The patients were treated for primitive stenosis, restenosis after balloon angioplasty and thermal laser angioplasty. Intimal hyperplasia was the distinctive feature of restenosis and the cells were identified by immunohistochemistry and transmission electron microscopy as smooth muscle cells in an active synthetic phenotype. No differences were found in the restenosis process after balloon angioplasty and laser thermal angioplasty. Directional atherectomy is a useful tool to ameliorate our knowledge in the restenosis process after invasive procedure of recanalization.
再狭窄是动脉再通装置的主要限制因素。定向斑块旋切术首次实现了通过经皮途径去除动脉粥样硬化斑块样本。对一组接受定向斑块旋切术治疗的股浅动脉疾病患者进行了研究。这些患者接受了原发性狭窄、球囊血管成形术和热激光血管成形术后再狭窄的治疗。内膜增生是再狭窄的显著特征，通过免疫组织化学和透射电子显微镜鉴定这些细胞为具有活跃合成表型的平滑肌细胞。在球囊血管成形术和激光热血管成形术后的再狭窄过程中未发现差异。定向斑块旋切术是一种有用的工具，可增进我们对再通侵入性手术后再狭窄过程的了解。
