Kensche Philip R, Oti Martin, Dutilh Bas E, Huynen Martijn A
Center for Molecular and Biomolecular Informatics, Nijmegen Center for Molecular Life Sciences, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Trends Genet. 2008 May;24(5):207-11. doi: 10.1016/j.tig.2008.02.003. Epub 2008 Mar 28.
The comparison of fully sequenced genomes enables the study of selective constraints that determine genome organisation. We show that, in fungi, adjacent divergently transcribed (<---->) genes are more conserved in orientation than convergent (--><--) or co-oriented (-->-->) gene pairs. Furthermore, the time divergent orientation of two genes is conserved correlates with the degree of their co-expression and with the likelihood of them being functionally related. The functional interactions of the proteins encoded by the conserved divergent gene pairs indicate a potential for protein function prediction in eukaryotes.
对全序列基因组的比较有助于研究决定基因组组织的选择限制。我们发现，在真菌中，相邻的反向转录（<---->）基因在方向上比同向（--><-->）或共向（-->-->)基因对更保守。此外，两个基因的反向时间取向保守性与其共表达程度以及它们功能相关的可能性相关。保守的反向基因对所编码蛋白质的功能相互作用表明在真核生物中进行蛋白质功能预测的潜力。
