Grande-García Araceli, del Pozo Miguel A
Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
Eur J Cell Biol. 2008 Sep;87(8-9):641-7. doi: 10.1016/j.ejcb.2008.02.001. Epub 2008 Mar 28.
Migration is a complex process in which cells move in a given direction either in response to changes in the extracellular environment or as a consequence of an intrinsic propensity for directional movement. Migration plays key roles in many physiological and pathological processes, including development, angiogenesis, tissue regeneration and metastasis. An important role in migration is played by caveolin-1 and caveolae. Caveolae compartmentalize intracellular signalling pathways to orchestrate cell migration. Caveolin-1 presents a polarized distribution in migrating cells and is linked to the cytoskeleton, and changes in its expression modulate migration. Although there are some discrepancies regarding the regulatory effect of caveolin-1, most studies show that it promotes cell movement and polarity. The importance of caveolin-1 has recently been reinforced by studies with Cav1(-/-) cells, which indicate that it establishes polarity during directional migration by coordinating Src kinase and Rho GTPase signalling.
细胞迁移是一个复杂的过程，在此过程中，细胞会根据细胞外环境的变化或由于内在的定向运动倾向而向特定方向移动。迁移在许多生理和病理过程中发挥着关键作用，包括发育、血管生成、组织再生和转移。小窝蛋白-1和小窝在迁移中起着重要作用。小窝将细胞内信号通路分隔开来，以协调细胞迁移。小窝蛋白-1在迁移细胞中呈极化分布，并与细胞骨架相连，其表达的变化会调节迁移。尽管关于小窝蛋白-1的调节作用存在一些差异，但大多数研究表明它能促进细胞运动和极性。最近，对Cav1(-/-)细胞的研究进一步强调了小窝蛋白-1的重要性，这些研究表明它通过协调Src激酶和Rho GTPase信号传导在定向迁移过程中建立极性。
