McGowan C M, McGowan T W, Patterson-Kane J C
Department of Equine and Small Animal Medicine, The University of Helsinki, P.O. Box 57, 00014, Helsinki, Finland.
Vet J. 2009 Jun;180(3):330-6. doi: 10.1016/j.tvjl.2008.01.008. Epub 2008 Mar 28.
The aim of this study was to determine the prevalence of equine polysaccharide storage myopathy (EPSM) in two populations of horses in the UK. Biopsy specimens from 94 horses presented to an abattoir (population 1), and 46 horses with neuromuscular disorders presented to a university referral hospital (population 2) were obtained over a period of 4years. Histological sections were examined by a veterinary pathologist for lesions including abnormal polysaccharide inclusions in myofibres. In population 1, a diagnosis of EPSM was made in 8% and non-specific myopathy in 33% of horses. In population 2, a diagnosis of EPSM was made in 22%, equine motor neurone disease (EMND) in 15% and non-specific myopathy in 37%. Within each population there was no difference in age, sex or breed distribution and muscle disease diagnosis. However, populations differed from each other in age and breed distributions and muscle disease diagnosis. EPSM was found in draft, Warmblood and related breeds and was diagnosed for the first time in cob-types. EMND was reported in 7/46 horses presented for neuromuscular disease and weakness, representing an important diagnosis in the UK. This study showed a high prevalence of EPSM and other myopathies in typical breeds of horses in the UK.
本研究的目的是确定英国两个马群中马多糖贮积性肌病（EPSM）的患病率。在4年的时间里，从一家屠宰场的94匹马（群体1）以及一家大学转诊医院的46匹患有神经肌肉疾病的马（群体2）获取了活检标本。兽医病理学家对组织切片进行检查，以查找包括肌纤维中异常多糖包涵体在内的病变。在群体1中，8%的马被诊断为EPSM，33%的马被诊断为非特异性肌病。在群体2中，22%的马被诊断为EPSM，15%的马被诊断为马运动神经元病（EMND），37%的马被诊断为非特异性肌病。在每个群体中，年龄、性别或品种分布以及肌肉疾病诊断方面均无差异。然而，两个群体在年龄、品种分布以及肌肉疾病诊断方面存在差异。EPSM在役用马、温血马及相关品种中被发现，首次在短腿马类型中被诊断出来。在因神经肌肉疾病和虚弱前来就诊的46匹马中，有7匹被报告患有EMND，这在英国是一项重要的诊断。这项研究表明，EPSM和其他肌病在英国典型马种中的患病率很高。
