Liang Yuanyuan, Carriere Kimmie Chough
Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Stat Methods Med Res. 2008 Dec;17(6):581-93. doi: 10.1177/0962280207081606. Epub 2008 Mar 28.
In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.
本文提出了一种用于序贯临床试验中治疗分配的新分配规则。分层随机胜者优先规则（SRPWR）是随机胜者优先规则向两种以上治疗的扩展。它适用于治疗成功概率取决于治疗方法和已知混杂因素（如患者年龄、性别和疾病状态）的情况。平均而言，证明SRPWR将更多患者分配到更好的治疗组，同时消除选择偏倚并允许对治疗有延迟反应。
