一名急性淋巴细胞白血病患儿的鼻脑型毛霉菌病：病例报告
Rhinocerebral mucormycosis in a child with acute lymphoblastic leukemia: a case report.
作者信息
Popa Gheorghe, Blag Cristina, Sasca Florina
机构信息
Department of Pediatric Oncology, Pediatric Clinic No 2, University of Medicine and Pharmacy, Iuliu Hatieganu Cluj-Napoca, Romania.
出版信息
J Pediatr Hematol Oncol. 2008 Feb;30(2):163-5. doi: 10.1097/MPH.0b013e31815c255f.
BACKGROUND
Mucormycosis is a life-threatening fungal infection in patients with predisposing conditions.
CASE REPORT
We report the case of a 7-year-old girl with acute lymphoblastic leukemia and rhinocerebral mucormycosis who successfully completed chemotherapy. The infection with Rhizopus genus was mycologically identified from nasal secretions and therapy was based on amphotericin B with surgical debridement. Chemotherapy was safely continued after resolution of the mycosis and the patient remains in continuous complete remission at 30 months.
CONCLUSIONS
Rhinocerebral mucormycosis in acute lymphoblastic leukemia is manageable with sequential therapy including, amphotericin B, surgery, and risk-adapted chemotherapy.
背景
毛霉病是一种在有易感因素的患者中可危及生命的真菌感染。
病例报告
我们报告一例7岁急性淋巴细胞白血病合并鼻脑型毛霉病的女孩，该患者成功完成了化疗。从鼻分泌物中经真菌学鉴定出根霉属感染，治疗以两性霉素B联合手术清创为基础。在真菌病消退后安全地继续进行化疗，患者在30个月时仍处于持续完全缓解状态。
结论
急性淋巴细胞白血病合并鼻脑型毛霉病可通过包括两性霉素B、手术及风险适应性化疗在内的序贯治疗进行控制。
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