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双侧恶性黑色素瘤转移至内耳道/桥小脑角:手术治疗与功能保留

Bilateral malignant melanoma metastases to the internal auditory canal/cerebellopontine angle: surgical management and preservation of function.

作者信息

Gerganov Venelin M, Hore Nirjhar, Herold Christian, Wrede Karsten, Stan Alexandru C, Samii Amir, Samii Madjid

机构信息

International Neuroscience Institute-Hannover, Hannover, Germany.

出版信息

J Neurosurg. 2008 Apr;108(4):803-7. doi: 10.3171/JNS/2008/108/4/0803.

Abstract

Although intracranial metastases of malignant melanomas are common, localization at the cerebellopontine angle (CPA) or in the internal auditory canal (IAC) is rare, and bilateral presentation especially so. We present the case of a 46-year-old Caucasian woman with bilateral IAC/CPA lesions and a prior history of malignant melanoma on the right leg. During preoperative investigations, the presence of the bilateral IAC/CPA lesions along with several radiologically identified lesions along the neural axis led to the suspicion that she had neurofibromatosis Type 2 despite her history of malignant melanoma and the lack of characteristic skin lesions and family history. Histopathological analysis of the resected lesion confirmed the intraoperative diagnosis of bilateral CPA malignant melanoma metastases. Surgical removal of the tumors via the retrosigmoid approach with preservation of normal bilateral facial nerve function and unilateral serviceable hearing, combined with control of the systemic disease, provided this patient with a near-normal quality of life for at least 42 months after the initial diagnosis of melanoma.

摘要

尽管恶性黑色素瘤的颅内转移很常见,但位于桥小脑角(CPA)或内耳道(IAC)的情况罕见,双侧出现的情况尤为罕见。我们报告一例46岁的白种女性,患有双侧IAC/CPA病变,既往有右腿恶性黑色素瘤病史。在术前检查期间,双侧IAC/CPA病变以及沿神经轴放射学确定的多个病变的存在,导致怀疑她患有2型神经纤维瘤病,尽管她有恶性黑色素瘤病史且缺乏特征性皮肤病变和家族史。对切除病变的组织病理学分析证实了术中对双侧CPA恶性黑色素瘤转移的诊断。通过乙状窦后入路手术切除肿瘤,同时保留双侧正常面神经功能和单侧有用听力,并结合控制全身疾病,使该患者在黑色素瘤初步诊断后至少42个月内生活质量接近正常。

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