Tibolone: the way to beat many a postmenopausal ailments.

OBJECTIVE

The effects of tibolone on climacteric symptoms, osteoporosis, cardiovascular disease, breasts and the endometrium are summarised, and its role in clinical practice is reviewed in this article.

BACKGROUND

Tibolone has tissue-specific effects on receptors and enzymes that influence the synthesis and metabolism of endogenous sexual steroid hormones.

METHODS

This evaluation was based on the findings from several randomised studies, which addressed the basic and clinical research on tibolone.

RESULTS/CONCLUSION: Clinical trials prove that tibolone is effective in the treatment of the menopausal symptoms and for the postponement and calming of symptoms accompanying age-related diseases. The findings of basic researchers that tibolone affects the metabolism of every cell, including malignant cells, opened a door to a whole new domain of research that has a promising future.