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先天性心脏病手术风险调整(RACHS):在单中心新生儿系列研究中,它作为高危人群预后的预测指标是否有用?

Risk adjustment for congenital heart surgery (RACHS): is it useful in a single-center series of newborns as a predictor of outcome in a high-risk population?

作者信息

Simsic Janet M, Cuadrado Angel, Kirshbom Paul M, Kanter Kirk R

机构信息

Children's Healthcare of Atlanta/Sibley Heart Center Cardiology, Atlanta, GA 30341, USA.

出版信息

Congenit Heart Dis. 2006 Jul;1(4):148-51. doi: 10.1111/j.1747-0803.2006.00026.x.

Abstract

OBJECTIVE

Risk adjustment for congenital heart surgery (RACHS) was developed to compare outcome data for pediatric patients undergoing cardiac surgery. RACHS stratifies anatomic diversity into 6 categories based on age, type of surgery performed, and similar in-hospital mortality. The purpose of this retrospective review was to evaluate the use of RACHS in a single-center series as a predictor of outcome in a high-risk newborn population.

METHODS

In 2003, 793 pediatric cardiac surgical operations (584 open; 209 closed) were performed at our institution. Mortality was 2.1%. Of the 793 operations, 114 were in newborns less than 15 days of age. These 114 newborns were stratified according to RACHS. Two patients could not be stratified and were excluded from analysis. Preoperative, operative, and postoperative variables were compared between the RACHS stratified newborns.

RESULTS

Unexpectedly, newborns in RACHS category 4 had lower birth weights (3.0 +/- 0.5 kg vs. 3.5 +/- 0.5 kg; P < .05) and a trend toward increased postoperative inotropic score (19 +/- 7 vs. 16 +/- 4), increased postoperative lactic acid (72 +/- 48 vs. 63 +/- 25), increased length of mechanical ventilation (23 +/- 72 days vs. 8 +/- 6 days), increased length of stay (34 +/- 72 days vs. 31 +/- 17 days), and increased mortality (16% vs. 11%) compared with newborns in RACHS category 6.

CONCLUSION

Limitations of risk assessment using RACHS in a single-center series of high-risk newborns include the lack of consideration of confounding variables. Further risk adjustments that include such confounding variables are warranted.

摘要

目的

先天性心脏病手术风险调整(RACHS)用于比较接受心脏手术的儿科患者的结果数据。RACHS根据年龄、所施行手术类型以及相似的住院死亡率将解剖学多样性分为6类。本回顾性研究的目的是评估在单中心系列研究中使用RACHS作为高危新生儿群体预后预测指标的情况。

方法

2003年,我们机构进行了793例小儿心脏外科手术(584例开胸手术;209例闭式手术)。死亡率为2.1%。在这793例手术中,114例为年龄小于15天的新生儿。这114例新生儿根据RACHS进行分层。2例患者无法分层,被排除在分析之外。对RACHS分层的新生儿的术前、术中及术后变量进行比较。

结果

出乎意料的是,与RACHS 6类新生儿相比,RACHS 4类新生儿出生体重较低(3.0±0.5 kg对3.5±0.5 kg;P<.05),术后有使用正性肌力药物评分增加的趋势(19±7对16±4)、术后乳酸水平升高(72±48对63±25)、机械通气时间延长(23±72天对8±6天)、住院时间延长(34±72天对31±17天)以及死亡率增加(16%对11%)。

结论

在单中心系列高危新生儿中使用RACHS进行风险评估的局限性包括未考虑混杂变量。有必要进行包括此类混杂变量的进一步风险调整。

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