Suppr超能文献

先天性心脏病手术修复后住院时间延长的预测因素

Predictors of Extended Length of Hospital Stay Following Surgical Repair of Congenital Heart Diseases.

作者信息

Azhar Ahmad Saeed, Aljefri Hasan Mohamed

机构信息

Pediatric Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Pediatric Cardiac Center of Excellence, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Pediatr Cardiol. 2018 Dec;39(8):1688-1699. doi: 10.1007/s00246-018-1953-1. Epub 2018 Aug 31.

Abstract

The purpose of this study is to evaluate post-operative length of stay (LOS) following surgical repair of congenital heart defects (CHD) and to investigate baseline pre-operative factors and predictors of post-operative LOS (pLOS). Retrospective chart review of all cases of corrective surgery for CHD performed at the Pediatric Cardiology Unit, King Abdulaziz University Hospital, Jeddah during January 2013-December 2016. Baseline demographics, clinical factors, pre-operative, intra-operative, post-operative cardiac and extra-cardiac complications were analyzed as independent factors of pLOS using stepwise linear regression. Kaplan-Meier (KM) survival analysis was used to analyze the correlation of pLOS (in days) with the independent variables and estimate the probability to exceeding a given pLOS. A total 191 patients (52.4% male, 49.7% aged ≤ 1 year) were included with a median [range] LOS = 10 [3, 158] days. Several baseline clinical factors were associated with longer pLOS such as complex CHD types (tetralogy of Fallot, transposition of great arteries, etc.), high-risk RACHS categories and low weight at surgery. Independent risk factors of pLOS included pre-operative hemoglobin level (unstandardized regression coefficient: B = 2.96, p = 0.036) as the only pre-operative predictor of LOS, besides intra-operative complications (B = 11.72, p = 0.009) and posto-perative factors including MV duration (B = 9.39, p < 0.001), diet/feeding problems (B = 10.27, p = 0.001) and drain tube stay (B = 3.82, p = 0.003). KM survival curves confirmed that these factors increased the probability for longer LOS. Post-operative LOS was associated with several baseline and peri-operative factors; however, it was independently predicted by abnormal baseline hemoglobin level, the occurrence of intra-operative complications, besides post-operative feeding problems, chest drain stay, and MV duration.

摘要

本研究的目的是评估先天性心脏病(CHD)手术修复后的术后住院时间(LOS),并调查术前基线因素及术后住院时间(pLOS)的预测因素。对2013年1月至2016年12月期间在吉达阿卜杜勒阿齐兹国王大学医院儿科心脏病科进行的所有CHD矫正手术病例进行回顾性病历审查。将基线人口统计学、临床因素、术前、术中和术后心脏及心脏外并发症作为pLOS的独立因素,采用逐步线性回归进行分析。采用Kaplan-Meier(KM)生存分析来分析pLOS(以天为单位)与自变量的相关性,并估计超过给定pLOS的概率。共纳入191例患者(男性占52.4%,49.7%年龄≤1岁),中位LOS为10天[范围:3至158天]。一些基线临床因素与较长的pLOS相关,如复杂CHD类型(法洛四联症、大动脉转位等)、高危RACHS分类以及手术时体重较低。pLOS的独立危险因素包括术前血红蛋白水平(未标准化回归系数:B = 2.96,p = 0.036),这是LOS的唯一术前预测因素,此外还有术中并发症(B = 11.72, p = 0.009)以及术后因素,包括机械通气(MV)持续时间(B = 9.39, p < 0.001)、饮食/喂养问题(B = 10.27, p = 0.001)和引流管留置时间(B = 3.82, p = 0.003)。KM生存曲线证实这些因素增加了LOS延长的概率。术后LOS与多个基线和围手术期因素相关;然而,它可由异常的基线血红蛋白水平、术中并发症的发生以及术后喂养问题、胸腔引流管留置时间和MV持续时间独立预测。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验