Gillespie Matthew, Kuijpers Marijn, Van Rossem Maike, Ravishankar Chitra, Gaynor J William, Spray Thomas, Clark Bernard
Cardiology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Congenit Heart Dis. 2006 Jul;1(4):152-60. doi: 10.1111/j.1747-0803.2006.00027.x.
The purpose of this study was to identify factors that influence postoperative intensive care unit length of stay (ICULOS) in infants less than 6 months of age undergoing congenital heart surgery.
Records from a single institution, from January 2000 to December 2000, were reviewed. For analysis, surgical severity was characterized using an ordinal scoring system, the Aristotle Basic Complexity Score (ABCS; range 1-4).
Of 221 infants, 63 had elective surgery, that is, admission to the cardiac intensive care unit after surgery, and 158 had nonelective surgery with admission to the cardiac intensive care unit preoperatively. Elective vs. Nonelective groups differed: ABCS (median 2 vs. 3, P < .001), age at surgery (mean 110 + 10.5 vs. 27 + 3.7 days, P < .001), ICULOS (median 3.5 vs. 7 days, P < .000), and mortality (0% vs. 12.7%P < .0001). Step-wise multiple regression was performed using the natural log of ICULOS as the dependent variable. Factors associated with longer ICULOS for all 221 patients included: increasing ABCS, preoperative organ-system failure, total support time (= cardiopulmonary bypass time + deep hypothermic circulatory arrest time), total hours of postoperative ventilatory support, the need for postoperative cardiac catheterization, postoperative necrotizing enterocolitis, and postoperative nasogastric feeds. Higher preoperative weight and surgical repair vs. palliation were associated with a decrease in ICULOS.
In conclusion, preoperative organ dysfunction, need for nasogastric feeding, and total support time may offer measurable variables useful in predicting that infant at greatest risk for extended ICULOS.
本研究旨在确定影响6个月以下接受先天性心脏手术婴儿术后重症监护病房住院时间(ICULOS)的因素。
回顾了一家机构2000年1月至2000年12月的记录。为了进行分析,使用序数评分系统(亚里士多德基本复杂性评分,ABCS;范围1-4)来表征手术严重程度。
在221名婴儿中,63名接受了择期手术,即术后入住心脏重症监护病房,158名接受了非择期手术,术前入住心脏重症监护病房。择期与非择期组存在差异:ABCS(中位数2对3,P <.001)、手术年龄(平均110 + 10.5对27 + 3.7天,P <.001)、ICULOS(中位数3.5对7天,P <.000)和死亡率(0%对12.7%,P <.0001)。以ICULOS的自然对数作为因变量进行逐步多元回归。与所有221名患者ICULOS延长相关的因素包括:ABCS增加、术前器官系统衰竭、总支持时间(=体外循环时间+深低温循环停滞时间)、术后通气支持总小时数、术后心脏导管检查的必要性、术后坏死性小肠结肠炎和术后鼻饲喂养。术前体重较高以及手术修复与姑息治疗相比与ICULOS减少相关。
总之,术前器官功能障碍、鼻饲喂养的必要性和总支持时间可能提供可测量的变量,有助于预测ICULOS延长风险最大的婴儿。