Goetzl Edward J
Department of Medicine, University of California, UC Box 0711, 533 Parnassus at 4th Avenue, San Francisco, CA 94143, USA.
Curr Allergy Asthma Rep. 2008 Mar;8(1):28-31. doi: 10.1007/s11882-008-0006-x.
Our evolving knowledge of the universe of immune cytokines has permitted more precise definition of the extensive involvement of many cell-derived protein factors in the mediation of allergic diseases and asthma. Several newly recognized cytokines, which are derived from epithelial cells of the respiratory system, skin, and gastrointestinal tract or intraepithelial T cells in the context of interactions with nonimmune parenchymal cells, have potent stimulatory or inhibitory effects on the differentiation and/or activities of T helper (Th) 2-type CD4 T cells. Their properties and effects are reviewed from the perspective of novel targets for antiallergic therapy.
我们对免疫细胞因子领域不断发展的认识，使我们能够更精确地界定许多细胞衍生的蛋白质因子在介导过敏性疾病和哮喘中所起的广泛作用。几种新发现的细胞因子，来源于呼吸系统、皮肤和胃肠道的上皮细胞，或在与非免疫实质细胞相互作用的情况下由上皮内T细胞产生，它们对辅助性T（Th）2型CD4 T细胞的分化和/或活性具有强大的刺激或抑制作用。本文从抗过敏治疗新靶点的角度对它们的特性和作用进行了综述。
