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支架孔隙率对侧壁动脉瘤模型血流动力学的影响。

Effects of stent porosity on hemodynamics in a sidewall aneurysm model.

作者信息

Liou Tong-Miin, Li Yi-Chen

机构信息

National Tsing Hua University, Hsinchu, Taiwan 30013, ROC.

出版信息

J Biomech. 2008;41(6):1174-83. doi: 10.1016/j.jbiomech.2008.01.025. Epub 2008 Apr 2.

Abstract

Computation and experiment have been complementarily performed to study the fluid flow inside a stented lateral aneurysm anchored on the straight parent vessel. The implicit solver was based on the time-dependent incompressible Navier-Stokes equations of laminar flow. Solutions were generated by a cell-center finite-volume method that used second-order upwind and second-order center flux difference splitting for the convection and diffusion term, respectively. The second-order Crank-Nicolson method was used in the time integration term. Experimental techniques used were flow visualization (FV) and particle tracking velocimetry (PTV). Experimentally, the straight afferent vessel had an inner diameter 10mm. The diameters of the aneurysmal orifice, neck, and fundus were 14, 10, and 15 mm, respectively, and the distance between the orifice and dome measured 20mm. A 30 mm long helix-shaped stent was tested. Four stent porosities of 100%, 70%, 50%, and 25% were examined. Volume-flow rate waveform of a cerebral artery was considered with a maximum Reynolds number of 250 and Womersley number of 3.9. Results are presented in terms of the pulsatile main and secondary flow velocity vector fields, the volume inflow rates into the aneurysm, and the wall shear stress (WSS) and wall pressure at the aneurysm dome. Some comparisons of computed results with the present FV and PTV results and with the data available from the literature are also made. The maximum flow velocity inside the aneurysm ostium and the WSS in the dome region at the peak flow can, respectively, be suppressed to less than 5% of the parent vessel bulk velocity (or 20% of the unstented case) and 8% of the unstented case if the stent porosity is smaller than 40% (about the porosity of the two-layer stents). In general, the three-layer stents seem not as effective as the two-layer stents in reducing the magnitude of aneurysm inflow rate and WSS.

摘要

通过计算和实验相结合的方式,研究了附着在直母血管上的带支架侧方动脉瘤内的流体流动。隐式求解器基于层流的时间相关不可压缩纳维 - 斯托克斯方程。通过单元中心有限体积法生成解,该方法分别对对流项和扩散项采用二阶迎风格式和二阶中心通量差分分裂。时间积分项采用二阶克兰克 - 尼科尔森方法。所使用的实验技术为流动可视化(FV)和粒子跟踪测速法(PTV)。实验中,直的传入血管内径为10mm。动脉瘤口、颈部和底部的直径分别为14mm、10mm和15mm,口与穹顶之间的距离为20mm。测试了一个30mm长的螺旋形支架。研究了100%、70%、50%和25%的四种支架孔隙率。考虑了脑动脉的体积流量波形,最大雷诺数为250,沃默斯利数为3.9。结果以脉动的主流和二次流速度矢量场、进入动脉瘤的体积流入率以及动脉瘤穹顶处的壁面剪应力(WSS)和壁面压力的形式呈现。还将计算结果与当前的FV和PTV结果以及文献中的数据进行了一些比较。如果支架孔隙率小于40%(约为双层支架的孔隙率),动脉瘤口内的最大流速和峰值流量时穹顶区域的WSS可分别抑制到小于母血管总体流速的5%(或无支架情况下的20%)和无支架情况下的8%。一般来说,三层支架在降低动脉瘤流入率和WSS的幅度方面似乎不如双层支架有效。

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