Szöke Andrei, Trandafir Anca, Dupont Marie-Estelle, Méary Alexandre, Schürhoff Franck, Leboyer Marion
Service de Psychiatrie Adulte, Hôpital Albert Chenevier, Créteil, France.
Br J Psychiatry. 2008 Apr;192(4):248-57. doi: 10.1192/bjp.bp.106.029009.
A wide range of cognitive deficits have been demonstrated in schizophrenia, but their longitudinal course remains unclear.
To bring together all the available information from longitudinal studies of cognitive performance in people with schizophrenia.
We carried out a meta-analysis of 53 studies. Unlike previous reviewers, we included all studies (regardless of the type of medication), analysed each variable separately and compared results with data from controls.
Participants with schizophrenia showed a significant improvement in most cognitive tasks. The available data for controls showed, with one exception (the Stroop test), a similar or greater improvement. Performance in semantic verbal fluency remained stable in both individuals with schizophrenia and controls.
Participants with schizophrenia displayed improvement in most cognitive tasks, but practice was more likely than cognitive remediation to account for most of the improvements observed. Semantic verbal fluency may be the best candidate cognitive endophenotype.
精神分裂症患者存在广泛的认知缺陷，但其纵向病程仍不清楚。
汇总精神分裂症患者认知表现纵向研究的所有可用信息。
我们对53项研究进行了荟萃分析。与之前的综述者不同，我们纳入了所有研究（无论药物类型），分别分析每个变量，并将结果与对照组数据进行比较。
精神分裂症患者在大多数认知任务中表现出显著改善。对照组的可用数据显示，除一项（斯特鲁普测验）外，有类似或更大的改善。精神分裂症患者和对照组的语义言语流畅性表现均保持稳定。
精神分裂症患者在大多数认知任务中表现出改善，但观察到的大部分改善更可能是由于练习而非认知康复。语义言语流畅性可能是最佳的候选认知内表型。
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