[前列腺素E2在骨转移性癌中的作用]
[Role of PGE2 in bone metastatic cancer].
作者信息
Inada Masaki, Miyaura Chisato
机构信息
Tokyo University of Agriculture and Technology, Department of Biotechnology and Life Science.
出版信息
Clin Calcium. 2008 Apr;18(4):466-72.
Prostaglandin E(2) is a crucial mediator to maintain physiological homeostasis and several disease progression. In this article, we summarized the roles of PGE(2) in bone resorptive metastatic model using B16 melanoma. An antagonist of EP4, a receptor subtype for PGE(2), suppressed RANKL expression in osteoblast and following osteoclast formation that was induced by B16, suggesting cancer induced bone resorption mediate PGE(2) production in host osteoblast is a key role of cancer metastasis to bone.
前列腺素E(2)是维持生理稳态和多种疾病进展的关键介质。在本文中，我们总结了前列腺素E(2)在使用B16黑色素瘤的骨吸收转移模型中的作用。前列腺素E(2)的一种受体亚型EP4的拮抗剂抑制了成骨细胞中RANKL的表达以及随后由B16诱导的破骨细胞形成，这表明癌症诱导的骨吸收介导宿主成骨细胞中前列腺素E(2)的产生是癌症骨转移的关键作用。
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