Dalevi Daniel, Eriksen Niklas
Department of Computing Science and Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden.
Bioinformatics. 2008 Jun 1;24(11):1332-8. doi: 10.1093/bioinformatics/btn111. Epub 2008 Apr 1.
The evolutionary distance inferred from gene-order comparisons of related bacteria is dependent on the model. Therefore, it is highly important to establish reliable assumptions before inferring its magnitude.
We investigate the patterns of dotplots between species of bacteria with the purpose of model selection in gene-order problems. We find several categories of data which can be explained by carefully weighing the contributions of reversals, transpositions, symmetrical reversals, single gene transpositions and single gene reversals. We also derive method of moments distance estimates for some previously uncomputed cases, such as symmetrical reversals, single gene reversals and their combinations, as well as the single gene transpositions edit distance.
从相关细菌的基因顺序比较中推断出的进化距离取决于模型。因此，在推断其大小之前建立可靠的假设非常重要。
我们研究细菌物种间点阵图的模式，目的是在基因顺序问题中进行模型选择。我们发现了几类数据，通过仔细权衡反转、转位、对称反转、单基因转位和单基因反转的贡献可以对其进行解释。我们还推导了一些先前未计算情况的矩估计距离方法，如对称反转、单基因反转及其组合，以及单基因转位编辑距离。
