多变量分析表明基因对精神分裂症的神经回路有影响。
Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia.
作者信息
Tura Emanuela, Turner Jessica A, Fallon James H, Kennedy James L, Potkin Steven G
机构信息
Departments of Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA.
出版信息
Neuroreport. 2008 Apr 16;19(6):603-7. doi: 10.1097/WNR.0b013e3282fa6d8d.
Abstract
We investigated the relationship of functional neurocircuitries and dopamine receptor D1 (DRD1) polymorphisms in schizophrenics during a working memory task. Participants performed the Serial Item Recognition Paradigm memory task during functional magnetic resonance imaging acquisition. We performed a data-driven multivariate analysis (partial least squares) to characterize brain network (covariance) patterns. Genetic testing identified two main genotypes. Accuracy did not differ between the groups. Covariance patterns of different areas (including the dorsolateral prefrontal cortex and the inferior parietal lobule) were inversely related between the two genotypes. Two groups of schizophrenic patients with similar symptomatology and performance on a working memory task, but with distinct dopamine receptor genotypes, may use distinct neural systems to retrieve information.
摘要
我们研究了精神分裂症患者在执行工作记忆任务期间功能神经回路与多巴胺受体D1（DRD1）多态性之间的关系。参与者在功能磁共振成像采集过程中执行系列项目识别范式记忆任务。我们进行了数据驱动的多变量分析（偏最小二乘法）来表征脑网络（协方差）模式。基因检测确定了两种主要基因型。两组之间的准确率没有差异。两种基因型之间，不同区域（包括背外侧前额叶皮层和顶下小叶）的协方差模式呈负相关。两组症状和工作记忆任务表现相似，但多巴胺受体基因型不同的精神分裂症患者，可能使用不同的神经系统来检索信息。
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本文引用的文献
1
The relationship between performance and fMRI signal during working memory in patients with schizophrenia, unaffected co-twins, and control subjects.
Schizophr Res. 2007 Jan;89(1-3):191-7. doi: 10.1016/j.schres.2006.08.016. Epub 2006 Oct 5.
2
Brain dopamine d1 receptors in twins discordant for schizophrenia.
Am J Psychiatry. 2006 Oct;163(10):1747-53. doi: 10.1176/ajp.2006.163.10.1747.
3
Neural correlates of working memory dysfunction in first-episode schizophrenia patients: an fMRI multi-center study.
Schizophr Res. 2007 Jan;89(1-3):198-210. doi: 10.1016/j.schres.2006.07.021. Epub 2006 Sep 28.
4
Two distinct functional networks for successful resolution of proactive interference.
Cereb Cortex. 2007 Jul;17(7):1650-63. doi: 10.1093/cercor/bhl076. Epub 2006 Sep 12.
5
A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia.
Biol Psychiatry. 2006 Jul 1;60(1):11-21. doi: 10.1016/j.biopsych.2005.11.012. Epub 2006 Feb 28.
6
Under the curve: critical issues for elucidating D1 receptor function in working memory.
Neuroscience. 2006 Apr 28;139(1):263-76. doi: 10.1016/j.neuroscience.2005.09.028. Epub 2005 Nov 28.
7
Partial least squares analysis of neuroimaging data: applications and advances.
Neuroimage. 2004;23 Suppl 1:S250-63. doi: 10.1016/j.neuroimage.2004.07.020.
8
Spatiotemporal analysis of event-related fMRI data using partial least squares.
Neuroimage. 2004 Oct;23(2):764-75. doi: 10.1016/j.neuroimage.2004.05.018.
9
Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.
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10
Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings.
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