人类免疫缺陷病毒感染儿童和青少年对甲型肝炎疫苗接种的抗体反应。

Antibody response to hepatitis A immunization among human immunodeficiency virus-infected children and adolescents.

作者信息

Siberry George K, Coller Ryan J, Henkle Emily, Kiefner Carolyn, Joyner Mary, Rogers Jamie, Chang Jennifer, Hutton Nancy

机构信息

Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

出版信息

Pediatr Infect Dis J. 2008 May;27(5):465-8. doi: 10.1097/INF.0b013e31816454a3.

DOI:10.1097/INF.0b013e31816454a3

PMID:18382387

Abstract

Seventy-one of 84 human immunodeficiency virus (HIV)-infected children [84.5% (95% confidence interval: 75-91.5%)] were hepatitis A virus (HAV) seropositive after 2 doses of HAV vaccine. Higher CD4% and HIV suppression were significantly associated with increased HAV seropositivity rate. In multivariate analysis, CD4 >or=25% and young age were independent predictors of HAV seropositivity. Of 7 children given a third HAV vaccine dose because of negative HAV antibody after 2 doses, 2 (29%) became seropositive.

摘要

84名感染人类免疫缺陷病毒（HIV）的儿童中，71名（84.5%，95%置信区间：75 - 91.5%）在接种2剂甲型肝炎病毒（HAV）疫苗后甲型肝炎病毒血清学检测呈阳性。较高的CD4%和HIV抑制水平与甲型肝炎病毒血清学阳性率增加显著相关。在多变量分析中，CD4≥25%和年龄较小是甲型肝炎病毒血清学阳性的独立预测因素。在2剂疫苗接种后因甲型肝炎病毒抗体阴性而接种第3剂甲型肝炎病毒疫苗的7名儿童中，2名（29%）血清学转为阳性。