抗生素都去哪儿了？
Where have All the Antibiotics Gone?
机构信息
Department of Microbiology and Immunology, Life Sciences Institute, Vancouver, British Columbia.
出版信息
Can J Infect Dis Med Microbiol. 2006 Sep;17(5):287-90. doi: 10.1155/2006/707296.
The discovery of antibiotics some 60 years ago was anticipated to herald the end of infectious diseases. However, microbial evolution and genetic jugglery have dispelled this notion; the constant increase in the appearance of resistant strains has not been matched by the introduction of new therapeutic agents. On the contrary, the dire need for novel antibiotics has coincided with a reduction in antibiotic discovery programs in the pharmaceutical industry. As a result, the treatment of microbial diseases has reached a point where many infections are essentially untreatable by the antimicrobial agents currently available. At the present time, numerous initiatives are being undertaken by physicians and by governments in an attempt to redress this situation. In addition, alternative approaches to antibiotics for the treatment of infectious diseases are being explored intensively.
抗生素的发现可以追溯到 60 年前，人们曾期望它能终结传染病。然而，微生物的进化和基因重组推翻了这一观点；耐药菌株的不断出现并没有伴随着新治疗药物的问世。相反，对新型抗生素的迫切需求与制药行业抗生素发现项目的减少不谋而合。结果，微生物疾病的治疗已经达到了许多感染基本上无法用现有抗菌药物治疗的地步。目前，医生和政府正在采取多项举措来解决这一问题。此外，还在积极探索用于治疗传染病的抗生素替代方法。
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