Ruiz J, Castro I, Calabuig E, Salavert M
Miguel Salavert Lletí. Unidad de Enfermedades Infecciosas. Hospital Universitario y Politécnico La Fe, Valencia. Av. Fernando Abril Martorell, nº 106; Valencia 46016. Spain.
Rev Esp Quimioter. 2017 Sep;30 Suppl 1:66-71.
The abuse and uncontrolled use of antibiotics has resulted in the emergence and spread of resistant bacteria. The utility of conventional antibiotics for the treatment of bacterial infections has become increasingly strained due to increased rates of resistance coupled with reduced rates of development of new agents. As a result, multidrug-resistant, extensively drug-resistant, and pan-drug-resistant bacterial strains are now frequently encountered. This has led to fears of a "post-antibiotic era" in which many bacterial infections could be untreatable. Alternative non-antibiotic treatment strategies need to be explored to ensure that a robust pipeline of effective therapies is available to clinicians. The new therapeutic approaches for bacterial infections (beyond antibiotics) may provide a way to extend the usefulness of current antibiotics in an era of multidrug-resistant (MDR) bacterial infections.
抗生素的滥用和无节制使用导致了耐药细菌的出现和传播。由于耐药率上升以及新抗生素研发速度减缓，传统抗生素在治疗细菌感染方面的效用日益受限。结果，现在经常遇到多重耐药、广泛耐药和全耐药的细菌菌株。这引发了人们对“后抗生素时代”的担忧，即在这个时代许多细菌感染可能无法治疗。需要探索替代性的非抗生素治疗策略，以确保临床医生能够获得一系列强有力的有效治疗方法。针对细菌感染的新治疗方法（不包括抗生素）可能为在多重耐药（MDR）细菌感染时代延长现有抗生素的效用提供一条途径。
