Kishida Tameko, Yabushita Hiromitsu, Wakatsuki Akihiko, Zhuo Lisheng, Kimata Koji
Department of Obstetrics and Gynecology, Aichi Medical University, School of Medicine, Aichi, Japan.
Connect Tissue Res. 2008;49(2):105-8. doi: 10.1080/03008200701818629.
The purpose of this study is to investigate whether serum hyaluronan (HA) and serum-derived HA-associated proteins (SHAP)-HA complex predict cervical ripening and premature delivery. Sera were obtained from 64 women with normal pregnancies, 20 with full term delivery, and 13 with threatened premature labor. Concentrations of HA and SHAP-HA complex in serum were measured by sandwich ELISA. Serum concentrations of HA and SHAP-HA complex did not differ within first, second, and third trimester groups. The serum SHAP-HA complex was elevated in the full term labor group more than in the third trimester group; however, the concentrations of serum HA did not differ between both groups. The HA and SHAP-HA complex levels in sera were higher in the premature labor group than in the second trimester group. In the premature labor group, the SHAP-HA complex levels were higher in the cases with Bishop scores more than 4 points when compared with the cases with Bishop scores of 4 points or less. Increased levels of SHAP-HA complex in sera are possible predictive markers for cervical ripening in premature labor.
本研究的目的是调查血清透明质酸（HA）和血清源性HA相关蛋白（SHAP）-HA复合物是否可预测宫颈成熟度和早产。从64例正常妊娠妇女、20例足月分娩妇女和13例先兆早产妇女中获取血清。采用夹心酶联免疫吸附测定法（ELISA）检测血清中HA和SHAP-HA复合物的浓度。血清HA和SHAP-HA复合物浓度在孕早期、孕中期和孕晚期组之间无差异。足月分娩组血清SHAP-HA复合物水平高于孕晚期组；然而，两组血清HA浓度无差异。早产组血清HA和SHAP-HA复合物水平高于孕中期组。在早产组中，Bishop评分大于4分的病例SHAP-HA复合物水平高于Bishop评分小于或等于4分的病例。血清中SHAP-HA复合物水平升高可能是早产宫颈成熟的预测标志物。
