使用含屈螺酮的复方口服避孕药治疗多毛症。

Treatment of hirsutism with combined pill containing drospirenone.

作者信息

Gregoriou Odisseas, Papadias Kostantinos, Konidaris Sokratis, Bakalianou Kostantina, Salakos Nikolaos, Vrachnis Nikolaos, Creatsas George

机构信息

Second Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, Athens, Greece.

出版信息

Gynecol Endocrinol. 2008 Apr;24(4):220-3. doi: 10.1080/09513590801948309.

DOI:10.1080/09513590801948309

PMID:18382909

Abstract

The aim of the present study was to evaluate the biochemical and clinical effects of the combined pill consisting of ethinyl estradiol (EE) and drospirenone (DRSP) in hirsute patients. Fifty-two adolescents or young women from Greece were treated with 30 mug EE and 3 mg DRSP for 1 year. Hirsutism was evaluated by the Ferriman-Gallway (FG) score in the initial visit and at 3, 6 and 12 months. Follicle-stimulating hormone, luteinizing hormone, etradiol, free and total testosterone (T), sex hormone-binding globulin (SHBG), androstenedione and dehydroepiandrosterone sulfate were determined at the same intervals. Hirsutism improved and FG scores reduced to 77.4%, 67.2% and 51.8% at 3, 6 and 12 months, respectively. Plasma SHBG levels rose, while free and total T levels reduced from the third month onwards. In conclusion, the EE/DRSP pill improves hirsutism in women via antiandrogenic and antimineralocorticoid action. The biochemical manifestations of hyperandrogenism are also improved.

摘要

本研究的目的是评估由炔雌醇（EE）和屈螺酮（DRSP）组成的复方口服避孕药对多毛症患者的生化及临床影响。52名来自希腊的青少年或年轻女性接受了30μg EE和3mg DRSP治疗，为期1年。在初次就诊时以及治疗3、6和12个月时，通过费里曼-高尔韦（FG）评分评估多毛症情况。在相同时间间隔测定促卵泡生成素、促黄体生成素、雌二醇、游离睾酮和总睾酮（T）、性激素结合球蛋白（SHBG）、雄烯二酮和硫酸脱氢表雄酮。多毛症得到改善，FG评分在3、6和12个月时分别降至77.4%、67.2%和51.8%。血浆SHBG水平升高，而游离T和总T水平从第三个月起降低。总之，EE/DRSP复方口服避孕药通过抗雄激素和抗盐皮质激素作用改善女性多毛症。高雄激素血症的生化表现也得到改善。