Toll样受体与真菌感染：TLR2、TLR4和MyD88在副球孢子菌病中的作用
Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis.
作者信息
Calich Vera L G, Pina Adriana, Felonato Maíra, Bernardino Simone, Costa Tania A, Loures Flávio V
机构信息
Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil.
出版信息
FEMS Immunol Med Microbiol. 2008 Jun;53(1):1-7. doi: 10.1111/j.1574-695X.2008.00378.x. Epub 2008 Apr 1.
The aim of this minireview is to present a concise view of the most important pattern recognition receptors used by the innate immune system to sense and control pathogen growth into host tissues. A brief review of the role of Toll-like receptors (TLRs) in fungal infections followed by some recent results on the function of TLR4, TLR2 and the MyD88 adaptor molecule in the pathogenesis of paracoccidioidomycosis are presented.
本综述的目的是简要介绍固有免疫系统用于感知和控制病原体在宿主组织中生长的最重要的模式识别受体。首先简要回顾Toll样受体（TLR）在真菌感染中的作用，接着介绍一些关于TLR4、TLR2和MyD88衔接分子在副球孢子菌病发病机制中功能的最新研究结果。
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