Varga J, Magyar K, Fodor L, Romváry A
Department of Microbiology and Infectious Diseases, University of Veterinary Science, Budapest, Hungary.
Acta Vet Hung. 1991;39(3-4):127-35.
The sensitivity of ten Bordetella bronchiseptica and ten Pasteurella multocida strains, each isolated from cases of atrophic rhinitis (AR), was examined in tube dilution test. Getroxel, chlorquinaldol and oxytetracycline and the former two ones combined with trimethoprim inhibited the growth of both species in vitro. The minimum inhibitory and the minimum bactericidal concentration was less than 0.5 microgram/ml. When efficacy was tested in SPF in the group fed a combination of Getroxel, chlorquinaldol and oxytetracycline (60 mg, 240 mg and 360 mg/kg of feed, respectively), P. multocida disappeared from the nasal cavity by the end of a 30-day treatment. B. bronchiseptica was reisolated in low numbers from 2 out of 9 piglets. The daily body mass gain was by 7.9% higher and the feed conversion rate was by 19% better than in the control group. After slaughter, only mild signs of AR were seen in 3 out of 9 piglets treated with the above-mentioned drug combination, while in the control group severe lesions were observed in 8 out of 9 pigs. In treated commercial herds P. multocida disappeared from the nasal cavity of the piglets by the end of the treatment (42nd day of life), but the B. bronchiseptica strains could not be completely eliminated. Due to the treatment, mortality between 2 and 6 weeks of age decreased by 0.8-7.6%. Daily body mass gain was, on the average, 16.4% higher, the amount of feed needed for 1 kg body mass gain was by 15.3% lower and the duration of fattening was by 30.8 days shorter than in the control groups.
采用试管稀释法检测了分别从萎缩性鼻炎（AR）病例中分离出的10株支气管败血波氏杆菌和10株多杀性巴氏杆菌的敏感性。加替沙星、氯喹那多、土霉素以及前两者与甲氧苄啶联用在体外均能抑制这两种菌的生长。最小抑菌浓度和最小杀菌浓度均小于0.5微克/毫升。在无特定病原体（SPF）猪群中进行药效试验时，给猪饲喂加替沙星、氯喹那多和土霉素的组合（分别为每千克饲料60毫克、240毫克和360毫克），到30天治疗结束时，多杀性巴氏杆菌从鼻腔消失。9头仔猪中有2头少量重新分离出支气管败血波氏杆菌。与对照组相比，日体重增加高出7.9%，饲料转化率提高了19%。屠宰后，用上述药物组合治疗的9头仔猪中有3头仅出现轻微的AR症状，而对照组9头猪中有8头观察到严重病变。在接受治疗的商品猪群中，到治疗结束时（出生后第42天），仔猪鼻腔中的多杀性巴氏杆菌消失，但支气管败血波氏杆菌菌株未能完全清除。由于进行了治疗，2至6周龄期间的死亡率降低了0.8 - 7.6%。平均日体重增加高出16.4%，每增加1千克体重所需的饲料量降低了15.3%，育肥期比对照组缩短了30.8天。
