Kuzuya Masafumi, Hirakawa Yoshihisa, Suzuki Yusuke, Iwata Mitsunaga, Enoki Hiromi, Hasegawa Jun, Iguchi Akihisa
Department of Geriatrics, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.
J Am Geriatr Soc. 2008 May;56(5):881-6. doi: 10.1111/j.1532-5415.2008.01676.x. Epub 2008 Apr 1.
To clarify the association between unmet medication management need and 3-year mortality and hospitalization for community-dwelling older people with various levels of disabilities.
Prospective cohort study (the Nagoya Longitudinal Study for Frail Elderly).
Community-based.
One thousand seven hundred seventy-two community-dwelling elderly subjects (611 men, 1,161 women).
Data included the clients' demographic characteristics, a rating for basic and instrumental activities of daily living (ADLs), number of prescribed medications and physician-diagnosed chronic diseases, medication adherence, ability to manage medication, and presence or absence of medication assistance. Cox proportional hazard models and the Kaplan-Meier method were used to assess the association between the medication management at baseline and mortality or hospitalization during a 3-year period.
Of 1,772 participants, 681 reported no difficulty with self-medication management, and 1,091 experienced difficulty with self-medication. Of participants with difficulty with self-medication management, 929 had medication assistance, and 162 did not. During a 3-year follow up, 424 participants died, and 758 were admitted to hospitals. The baseline data demonstrated that participants not receiving medication assistance were younger and had better ADL status and fewer comorbidities. Multivariate Cox regression models adjusting for potential confounders showed that the lack of assistance in those who needed medication assistance was associated with hospitalization but not mortality during the study period.
In community-dwelling disabled elderly people, lack of medication assistance in those needing medication support was associated with higher risk of hospitalization.
明确社区居住的不同残疾程度老年人未满足的药物管理需求与3年死亡率及住院率之间的关联。
前瞻性队列研究(名古屋虚弱老年人纵向研究)。
以社区为基础。
1772名社区居住的老年受试者(611名男性,1161名女性)。
数据包括受试者的人口统计学特征、日常生活基本活动和工具性活动(ADL)评分、处方药数量和医生诊断的慢性病、用药依从性、药物管理能力以及是否有药物协助。采用Cox比例风险模型和Kaplan-Meier方法评估基线时的药物管理与3年期间死亡率或住院率之间的关联。
在1772名参与者中,681名报告自我药物管理无困难,1091名自我药物管理有困难。在自我药物管理有困难的参与者中,929名有药物协助,162名没有。在3年随访期间,424名参与者死亡,758名住院。基线数据显示,未接受药物协助的参与者更年轻,ADL状态更好,合并症更少。调整潜在混杂因素的多变量Cox回归模型显示,在需要药物协助的人群中,缺乏协助与研究期间的住院率相关,但与死亡率无关。
在社区居住的残疾老年人中,需要药物支持的人群缺乏药物协助与更高的住院风险相关。