Taguchi Reina, Okada Akira, Tsuchiya-Ito Rumiko, Kitamura Satomi, Ishikawa Tomoki, Hamada Shota
Research Department, Institute for Health Economics and Policy, Association for Health Economics Research and Social Insurance and Welfare, Tokyo, Japan.
Department of Clinical Epidemiology and Health Economics, School of Public Health, the University of Tokyo, Tokyo, Japan.
Pharmacol Res Perspect. 2025 Aug;13(4):e70152. doi: 10.1002/prp2.70152.
This study describes the continuity of visiting pharmacist services and investigates factors associated with service discontinuation in a homebound older population in Japan. This retrospective cohort study used medical and long-term care claims data from older adults aged ≥ 65 years in a city in Tokyo, Japan, who began to receive visiting pharmacist services between April 2014 and March 2019. Participants were followed until service cessation (defined as the absence of service claims for 2 consecutive months) or 12 months from initiation. Reasons for cessation were categorized into death, relocation, hospitalization/institutionalization, or discontinuation based on claims data. Multivariable competing-risk Cox regression analysis determined factors associated with discontinuation. Death and hospitalization/institutionalization were considered competing risks, and relocation was considered non-informative censoring. The study included 3952 older adults, with 353 (8.9%) having terminal cancer. The median time to any-cause cessation was 11 and 2 months for all participants and those with terminal cancer, respectively. Death was the most common reason for cessation, with a 12-month cumulative incidence of 0.25 (95% confidence interval: 0.24-0.27). Factors associated with a lower likelihood of discontinuation included higher long-term care need levels, polypharmacy of more than five medications, recent hospitalization, and cancer diagnosis. Conversely, living at home compared to residential facilities, ischemic heart disease, and receiving services from pharmacies providing 24-h support were linked to a higher discontinuation risk. This study enhances the current understanding of continuity in visiting pharmacist services for older adults. Care should be tailored, considering factors influencing service duration and potential discontinuation.
本研究描述了上门访视药剂师服务的连续性,并调查了日本居家老年人群中与服务中断相关的因素。这项回顾性队列研究使用了来自日本东京某城市65岁及以上老年人的医疗和长期护理理赔数据,这些老年人在2014年4月至2019年3月期间开始接受上门访视药剂师服务。对参与者进行随访,直至服务停止(定义为连续2个月无服务理赔)或从开始服务起12个月。根据理赔数据,停止服务的原因分为死亡、搬迁、住院/入住机构或中断服务。多变量竞争风险Cox回归分析确定了与服务中断相关的因素。死亡和住院/入住机构被视为竞争风险,而搬迁被视为非信息性删失。该研究纳入了3952名老年人,其中353名(8.9%)患有晚期癌症。所有参与者和患有晚期癌症的参与者因任何原因停止服务的中位时间分别为11个月和2个月。死亡是停止服务最常见的原因,12个月累积发病率为0.25(95%置信区间:0.24 - 0.27)。与较低服务中断可能性相关的因素包括较高的长期护理需求水平、使用五种以上药物的多药合用情况、近期住院和癌症诊断。相反,与居住在养老机构相比,居家生活、缺血性心脏病以及从提供24小时支持的药房接受服务与较高的服务中断风险相关。本研究增进了目前对老年人上门访视药剂师服务连续性的理解。应根据影响服务持续时间和潜在中断的因素进行个性化护理。