Cline Mark A, Fouse Dawn N, Prall Brian C
Department of Biology (6931), Radford University, Radford, VA 24142, USA.
Neuropeptides. 2008 Jun;42(3):283-91. doi: 10.1016/j.npep.2008.02.004. Epub 2008 Apr 1.
We studied the effects of alytesin, a natural analogue of bombesin, on appetite-related responses and behaviors in neonatal chicks. Chicks responded to both intracerebroventricular (ICV) and peripheral injections of alytesin with short-term reduced feed intake. ICV alytesin caused reduced short-term water intake when feed was present, but we determined this effect was secondary to feed intake since an effect on water intake was not detected in feed-restricted alytesin-treated chicks. The anorexigenic effect of both ICV and peripheral alytesin may be mediated at the hypothalamus, since all hypothalamic nuclei studied; regio lateralis hypothalami, nucleus dorsomedialis hypothalami, nucleus paraventricularis magnocellularis, nucleus perventricularis hypothalami, nucleus infundibuli hypothalami and the nucleus ventromedialis hypothalami, were activated as evident by increased c-Fos immunoreactivity. Central alytesin did not cause increased behaviors that were unrelated to ingestion and did not cause anxiety-related behavior patterns. Additionally, central alytesin did not affect pecking efficacy. We conclude that both ICV and peripheral alytesin injections induce anorexigenic effects in chicks, and the hypothalamus is involved. While the anorexigenic effects of alytesin and bombesin appear to be conserved across species, the two peptides may differ in other behavioral responses and central mechanisms of action.
我们研究了铃蟾肽的天然类似物阿利替辛对新生雏鸡食欲相关反应和行为的影响。雏鸡对脑室内（ICV）和外周注射阿利替辛均有短期采食量减少的反应。当有饲料时，脑室内注射阿利替辛会导致短期饮水量减少，但我们确定这种影响是采食量减少的继发效应，因为在限饲的阿利替辛处理雏鸡中未检测到对饮水量的影响。脑室内和外周注射阿利替辛的厌食作用可能在下丘脑介导，因为所研究的所有下丘脑核团；下丘脑外侧区、下丘脑背内侧核、室旁大细胞核、下丘脑室周核、下丘脑漏斗核和下丘脑腹内侧核，均因c-Fos免疫反应性增加而被激活。中枢注射阿利替辛不会导致与摄食无关的行为增加，也不会导致与焦虑相关的行为模式。此外，中枢注射阿利替辛不影响啄食效率。我们得出结论，脑室内和外周注射阿利替辛均可诱导雏鸡产生厌食作用，且下丘脑参与其中。虽然阿利替辛和铃蟾肽的厌食作用似乎在不同物种间具有保守性，但这两种肽在其他行为反应和中枢作用机制上可能存在差异。
