Heidemann F, Steinke W, Pleiss U, Theiss G, Voges K P, Kazda S, Gerzer R, Stasch J P
Institute of Pharmacology, Bayer A.G. Research Center, Wuppertal, Federal Republic of Germany.
Histochemistry. 1991;96(4):317-21. doi: 10.1007/BF00271352.
Whole-body autoradiography demonstrated the different distribution of [125I]-C-ANP and [125I]-ANP to rat tissues. Highest enrichment of radioactivity of both labelled peptides was found in the kidney. In some organs we found remarkable differences between [125I]-ANP and [125I]-C-ANP. In the kidney cortex, especially in the glomeruli, as well as in the endocardium, the zona glomerulosa and the medulla of the adrenal gland, where high levels of radioactivity after [125I]-ANP administration were detected, no or just few radioactivity was found after administration of [125I]-C-ANP. On the other hand in the kidney papilla and the outer subcortical medulla, characteristic blackening was found after [125I]-C-ANP administration. Those differences might be important for the understanding of pharmacological actions of ANP analogues.
全身放射自显影显示了[125I]-C-ANP和[125I]-ANP在大鼠组织中的不同分布。两种标记肽的放射性最高富集出现在肾脏。在一些器官中，我们发现[125I]-ANP和[125I]-C-ANP之间存在显著差异。在肾皮质，尤其是肾小球，以及心内膜、肾上腺球状带和髓质中，在给予[125I]-ANP后检测到高水平的放射性，但在给予[125I]-C-ANP后未发现或仅发现少量放射性。另一方面，在肾乳头和皮质下髓质外层，给予[125I]-C-ANP后出现特征性变黑。这些差异可能对理解ANP类似物的药理作用很重要。
