通过钯催化的氢转移反应从炔丙基胺合成单取代和 1,3 - 二取代的丙二烯。

Synthesis of mono- and 1,3-disubstituted allenes from propargylic amines via palladium-catalysed hydride-transfer reaction.

作者信息

Nakamura Hiroyuki, Ishikura Makoto, Sugiishi Tsuyuka, Kamakura Takaya, Biellmann Jean-François

机构信息

Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171-8588, Japan.

出版信息

Org Biomol Chem. 2008 Apr 21;6(8):1471-7. doi: 10.1039/b718298h. Epub 2008 Mar 6.

DOI:10.1039/b718298h

PMID:18385854

Abstract

Mono- and 1,3-disubstituted allenes were synthesized from the corresponding propargylamines via palladium-catalysed hydride-transfer reaction. In the current transformation, propargylic amines can be handled as allenyl anion equivalents and introduced into various electrophiles to be transformed into allenes under palladium-catalyzed conditions.

摘要

单取代和 1,3 - 二取代丙二烯通过钯催化的氢转移反应由相应的炔丙胺合成。在当前的转化反应中，炔丙胺可作为丙二烯基阴离子等价物进行处理，并在钯催化条件下引入各种亲电试剂中转化为丙二烯。