香豆素的抗真菌活性。

Antifungal activity of coumarins.

作者信息

Montagner Cristina, de Souza Simone M, Groposoa Cláudia, Delle Monache Franco, Smânia Elza F A, Smânia Artur

机构信息

Departamento de Microbiologia e Parasitologia, Centro de Ciências Biológicas da Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis-SC 88040-900, Brazil.

出版信息

Z Naturforsch C J Biosci. 2008 Jan-Feb;63(1-2):21-8. doi: 10.1515/znc-2008-1-205.

DOI:10.1515/znc-2008-1-205

PMID:18386483

Abstract

The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 microg/ml for Fusarium solani and 250 micro/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.

摘要

采用肉汤微量稀释法，测试了40种香豆素对白色念珠菌（ATCC 14053）、烟曲霉（ATCC 16913）和茄病镰刀菌（ATCC 36031）等真菌菌株的抗真菌活性。在所有测试化合物中，欧前胡醇表现出最有效的抗真菌活性，对茄病镰刀菌的最低抑菌浓度（MIC）值为125微克/毫升，对白色念珠菌和烟曲霉的MIC值为250微克/毫升。这种异戊烯基化香豆素的抗真菌潜力可能与C-8位存在烷基有关。