Brimkulov N N
Ter Arkh. 1991;63(8):25-30.
As many as 132 patients with bronchial asthma were examined for the clinical, functional and laboratory parameters before and during alpine climatotherapy at a height of 3200 m above the sea level (the Tyuya-Ashu pass, the northern Tien Shan). In addition to the improvement of the general status, the patients manifested amelioration of ventilation and decreased responsiveness of the bronchial tree by the end of alpine climatotherapy. Favourable alterations in the immune parameters together with appreciable stimulation of steroidogenesis in the adrenals were discovered. Investigation into surface activity of the exhaled air condensate revealed activation of the surfactant system. These data and endoscopy with bronchoalveolar lavage confirmed the reduction of the inflammatory lesions in the tracheobronchial tree. Therefore, alpine climatotherapy produces a favourable effect on the main mechanisms of the disease development and can be used on a wider basis for the treatment of patients suffering from bronchial asthma.
对多达132例支气管哮喘患者在海拔3200米（天山北部图亚-阿舒山口）进行高山气候疗法之前及期间的临床、功能和实验室参数进行了检查。除了一般状况改善外，患者在高山气候疗法结束时还表现出通气改善以及支气管树反应性降低。发现免疫参数有有利变化，同时肾上腺类固醇生成受到明显刺激。对呼出空气冷凝物表面活性的研究显示表面活性剂系统被激活。这些数据以及支气管肺泡灌洗的内窥镜检查证实气管支气管树的炎症病变减轻。因此，高山气候疗法对疾病发展的主要机制产生有利影响，可更广泛地用于治疗支气管哮喘患者。
