Diykov Dmitry, Barmashenko Gleb, Hoffmann Klaus-Peter
International Graduate School of Neuroscience, General Zoology and Neurobiology, Ruhr University Bochum, Bochum, Germany.
Neuroreport. 2008 Mar 26;19(5):595-8. doi: 10.1097/WNR.0b013e3282f9e43c.
Albinism has a profound effect on visual development and visual function. Pharmacologically significant alterations of the two most important chloride-transporters--KCC2 (outward transporter) and NKCC1 (inward transporter)--functions were found in albino visual cortex neurons, comprising a higher NKCC1 and a lower KCC2 action. In this study, we compare the early postnatal development of the reversal potential of gamma-aminobutyric acidAR-mediated currents in visual cortex neurons of albino and pigmented rats. At birth we found no differences. At the time of eye opening (second week postnatally) the reversal potential of gamma-aminobutyric acidAR-mediated currents is 15 mV more positive and intracellular Cl- concentration is higher in visual cortex neurons of albinos than of pigmented rats.
白化病对视神经发育和视觉功能有深远影响。在白化病视觉皮层神经元中发现了两种最重要的氯离子转运体——KCC2（外向转运体）和NKCC1（内向转运体）功能的药理学显著改变，包括NKCC1活性较高和KCC2活性较低。在本研究中，我们比较了白化病大鼠和有色大鼠视觉皮层神经元中γ-氨基丁酸AR介导电流的反转电位在出生后的早期发育情况。出生时我们未发现差异。在睁眼时（出生后第二周），白化病大鼠视觉皮层神经元中γ-氨基丁酸AR介导电流的反转电位比有色大鼠的更正15 mV，且细胞内氯离子浓度更高。
